Home Chemistry Heterocyclic Building Blocks Pyridines Pyridine-3-Sulfonyl Chloride
Nucleophilic substitution reactions: The sulfonyl chloride group is highly reactive towards nucleophiles. This can result in the substitution of the chlorine atom with a nucleophile, leading to the formation of sulfonamide derivatives.
Acylation reactions: Pyridine-3-sulfonyl chloride can undergo acylation reactions with nucleophilic species, such as amines or alcohols, resulting in the formation of sulfonamide or sulfonate esters derivatives, respectively.
Dehydrohalogenation reactions: Under certain conditions, pyridine-3-sulfonyl chloride can undergo elimination reactions, leading to the formation of unsaturated products.
Reduction reactions: The sulfonyl chloride group can be reduced to a sulfonyl hydrazide or sulfonamide under appropriate reaction conditions.
Cross-coupling reactions: Pyridine-3-sulfonyl chloride can participate in transition-metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig reactions, for the synthesis of biaryl compounds or amine derivatives, respectively.
Cyclization reactions: Depending on the reaction conditions and the structure of the substrate, pyridine-3-sulfonyl chloride can participate in cyclization reactions, leading to the formation of cyclic sulfonamide derivatives.
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6-Chloro-5-methoxypyridine-3-sulfonyl chloride
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2-Chloro-5-methylpyridine-3-sulfonyl chloride
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5-Bromo-6-chloropyridine-3-sulfonyl chloride
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6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride
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6-Chloro-2-methylpyridine-3-sulfonyl chloride
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6-Chloro-5-fluoropyridine-3-sulfonyl chloride
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2,5-Dichloropyridine-3-sulfonyl chloride
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2-Chloro-4-methyl-pyridine-3-sulphonyl chloride
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6-Chloro-4-methylpyridine-3-sulfonyl chloride
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2-Chloro-6-methoxypyridine-3-sulfonyl chloride
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