Filamin-A is a member of the Filamin protein family, primarily consisting of a hinge structure and multiple Ig-like domains. It is mainly localized in the cytoplasm and associated with the stabilization and reorganization of the cytoskeleton. Filamin-A participates in various signaling pathways, such as cell migration, division, and signal transduction, which are crucial for maintaining cellular morphology and functionality. It is specifically expressed in various cell types, and mutations often lead to developmental abnormalities and diseases such as cardiovascular and musculoskeletal disorders.