Chemistry Heterocyclic Building Blocks Cinnolines
Cinnoline, which has the chemical formula C8H6N2, is an aromatic heterocyclic compound which is isomeric with other naphthyridines including quinoxaline, phthalazine, and quinazoline.
Pharmaceutically and biologically significant, cinnolines exhibit various activities such as anticancer, antimicrobial, anti-inflammatory, antiparasitic, and foliar herbicide.
The preparation of cinnolines, which are one of the two benzoderivatives of pyridazines, primarily involves the condensation of hydrazine derivatives with carbonyl compounds, followed by the closure of the resulting ring in various ways.
Cinnolines exhibit a range of pharmaceutical activities, including anticancer, antibacterial, anti-inflammatory, anti-allergic, and anti-hypertensive effects.
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3-Chloro-4-(2,6-dimethoxyphenyl)cinnoline
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2,3-Dihydrocinnolin-4(1H)-one hydrochloride
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7-Bromo-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid
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7-Chloro-8-methyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid