Chemistry
Organic Building Blocks
Hydrazones
Hydrazones are a type of organic compounds characterized by the presence of the structure R1R2C=N−NH2. They share similarities with ketones and aldehydes, but instead of the oxygen =O group, they have a =N−NH2 functional group.
Hydrazine, as well as its derivatives such as organohydrazines and 1,1-diorganohydrazines, are capable of undergoing reactions with aldehydes and ketones to form hydrazones.
Hydrazones serve as a fundamental component in bioconjugation strategies.
Typically, hydrazones are synthesized through the reaction of hydrazine with ketones or aldehydes, leading to the replacement of the oxygen atom with the hydrazine moiety.
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N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
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(E)-tert-Butyl 2-benzylidenehydrazinecarboxylate
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2-(2,4-Dichlorobenzylidene)hydrazinecarboximidamide
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
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Ethyl 2-chloro-2-(2-phenylhydrazono)acetate
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N-(4-((2-Carbamothioylhydrazono)methyl)phenyl)acetamide
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2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide
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(Z)-2,2,2-Trifluoro-N'-(piperazin-2-ylidene)acetohydrazide
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2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide
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(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
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N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
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3-Methyl-4-(((5-nitrofuran-2-yl)methylene)amino)thiomorpholine 1,1-dioxide
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N'-(Pyridin-4-ylmethylene)isonicotinohydrazide
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N'1,N'2-Dicyclohexylideneoxalohydrazide