Chemistry Organic Building Blocks Hydrazones
Hydrazones are a type of organic compounds characterized by the presence of the structure R1R2C=N−NH2. They share similarities with ketones and aldehydes, but instead of the oxygen =O group, they have a =N−NH2 functional group.
Hydrazine, as well as its derivatives such as organohydrazines and 1,1-diorganohydrazines, are capable of undergoing reactions with aldehydes and ketones to form hydrazones.
Hydrazones serve as a fundamental component in bioconjugation strategies.
Typically, hydrazones are synthesized through the reaction of hydrazine with ketones or aldehydes, leading to the replacement of the oxygen atom with the hydrazine moiety.
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2-Hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole hydrochloride
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N'-(Pyridin-4-ylmethylene)isonicotinohydrazide
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2-Hydrazono-5-methyl-1,2-dihydropyrimidine
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(E)-tert-Butyl 2-benzylidenehydrazinecarboxylate
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tert-Butyl 2-(pyridin-2-ylmethylene)hydrazinecarboxylate
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2-Oxo-N-phenylpropanehydrazonoyl chloride
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tert-Butyl 2-cyclohexylidenehydrazinecarboxylate
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(Z)-2,2,2-Trifluoro-N'-(piperazin-2-ylidene)acetohydrazide
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tert-Butyl 2-(propan-2-ylidene)hydrazinecarboxylate
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2-Cyclopentylidenehydrazine-1-carbothioamide
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate