Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1,2-Difluoro-4-Methoxybenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—OCH3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Aluminum Chloride Demethylation: Methoxybenzene can be demethylated using aluminum chloride (AlCl3) as a catalyst, leading to the formation of 【phenol|https://www.ambeed.com/phenols.html】 and methanol.
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(4,5-Difluoro-2-methoxyphenyl)boronic acid
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2-(4,5-Difluoro-2-methoxyphenyl)acetonitrile
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2,3-Difluoro-6-methoxyphenylboronic acid
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1,2,3-Trifluoro-5-methoxy-4-nitrobenzene
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