Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromonicotinic Acid
Substitution Reactions: The bromine atom can undergo substitution reactions with various nucleophiles, such as amines or hydroxide ions, leading to the formation of substituted derivatives of 2-bromonicotinic acid.
Acid-Base Reactions: 2-Bromonicotinic acid can undergo acid-base reactions, where it can donate a proton from the carboxylic acid group or accept a proton on the nitrogen atom of the pyridine ring, depending on the pH of the medium.
Esterification: 2-Bromonicotinic acid can react with alcohols in the presence of an acid catalyst to form esters. The carboxylic acid group undergoes nucleophilic acyl substitution with the alcohol, resulting in the formation of an ester.
Decarboxylation: Under certain conditions, such as heating or catalysis, 2-bromonicotinic acid can undergo decarboxylation, where the carboxyl group is removed as carbon dioxide, leading to the formation of a substituted pyridine derivative.
Reduction: 2-Bromonicotinic acid can be reduced to produce a variety of products depending on the reagents and conditions used. For instance, it can be reduced to the corresponding alcohol or further to the corresponding alkane.
Halogenation: The pyridine ring in 2-bromonicotinic acid can undergo further halogenation reactions, particularly if treated with strong halogenating agents, leading to the introduction of additional halogen atoms onto the ring.
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2-Bromo-4-(trifluoromethyl)nicotinic acid
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