Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromo-6-Iodopyridine
Substitution Reactions: The bromine and iodine atoms are susceptible to nucleophilic substitution reactions, where they can be replaced by various nucleophiles. For example, nucleophilic substitution with a strong nucleophile like NaN3 could lead to the formation of 2-azido-6-iodopyridine.
Cross-Coupling Reactions: The halogen atoms in 2-bromo-6-iodopyridine can undergo palladium-catalyzed cross-coupling reactions with various organometallic reagents or aryl halides to form biaryl compounds or other functionalized products.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases like butyl lithium or lithium diisopropylamide (LDA) to form organometallic intermediates, which can then be subjected to further reactions.
Reductive Elimination: Under appropriate conditions, the bromine and iodine atoms can undergo reductive elimination reactions, especially in the presence of reducing agents or transition metal catalysts.
Electrophilic Aromatic Substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions with various electrophiles, leading to substitution at the 2- and/or 6-position of the pyridine ring.
Functional Group Transformations: The halogen atoms can serve as functional groups for further transformations, such as oxidation, reduction, or conversion to other functional groups.
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