Chemistry Heterocyclic Building Blocks Morpholines

Morpholines

The chemical formula of morpholine is O(CH2CH2)2NH, which contains both amine and ether functional groups, making it an organic heterocycle.

Morpholine, a colorless liquid with a fishy odor, possesses a flash point of 100°F and can corrode tissue. It is less dense than water and can dissolve in water, while its vapors are denser than air.

Organic synthesis extensively employs morpholine, which serves as a fundamental component in manufacturing various compounds such as the antibiotic linezolid, the anticancer drug gefitinib (Iressa), and the analgesic dextromoramide.

Morpholine serves as a solvent for various organic compounds, including resins, dyes, and waxes. In organic synthesis, morpholine-based enamines have broad applications in the formation of C-C and C-X bonds.

Several pharmaceuticals, such as antibiotics, anticancer agents, and analgesics, are prepared using morpholines.

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(R)-3-phenylmorpholine (S)-3-phenylmorpholine 2,2-dimethylmorpholine 2,6-dimethylmorpholine 2-(methoxymethyl)morpholine 2-(morpholin-2-yl)acetic acid 2-ethylmorpholine 2-isopropylmorpholine 2-methylmorpholine 2-phenylmorpholine 3-(4-morpholinophenyl)oxazolidin-2-one 3-(methoxymethyl)morpholine 3-ethylmorpholine 3-isopropylmorpholine 3-methylmorpholine 3-phenylmorpholine 4-(2-fluorophenyl)morpholine 4-(3-phenoxypropyl)morpholine 4-(o-tolyl)morpholine 4-(pyrazin-2-yl)morpholine 4-(pyridin-4-yl)morpholine 4-(pyrimidin-2-yl)morpholine 4-benzylmorpholin-3-one 4-morpholinoaniline 4-morpholinobenzaldehyde 4-morpholinobenzoic acid 4-phenylmorpholin-3-one 6,6-dimethylmorpholine-3-carboxylic acid benzyl morpholine-4-carboxylate ethyl morpholine-2-carboxylate methyl 2-(morpholin-3-yl)acetate methyl morpholine-2-carboxylate methyl morpholine-3-carboxylate morpholin-2-ylmethanamine morpholin-2-ylmethanol morpholin-3-ylmethanol morpholine-2-carbonitrile morpholine-2-carboxylic acid morpholine-3-carboxylic acid morpholino(phenyl)methanone tert-butyl (morpholin-2-ylmethyl)carbamate tert-butyl 2-(bromomethyl)morpholine-4-carboxylate tert-butyl morpholine-4-carboxylate

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dioxaborolane-morpholine hydroxyethyl-morpholine morpholin-hydrochloride morpholin-methanol morpholine-carboxylic-acid morpholine-nitrile morpholinecarboxylate morpholino-methanone morpholinone morpholinopyridine phenylmorpholine pyrazo-morpholine pyridyl-morpholine pyrimidine-morpholine trifluoromethyl-phenyl-morpholine

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    4'-Morpholinoacetophenone

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    A64086039910-98-098%

    4'-Morpholinoacetophenone

    $94.00/25g

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    6-(Hydroxymethyl)morpholin-3-one

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    A303237929019-95-495%

    6-(Hydroxymethyl)morpholin-3-one

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    (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid

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    A140815884512-77-095%

    (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid

    $23.00/1g

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    2-Methyl-2-morpholinopropanal

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    A25497716042-91-495%

    2-Methyl-2-morpholinopropanal

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    (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide

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    A430084102562-74-397%

    (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide

    $27.00/100mg

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    Potassium trifluoro(3-fluoro-2-morpholinopyridin-4-yl)borate

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    A4871011704704-31-395%

    Potassium trifluoro(3-fluoro-2-morpholinopyridin-4-yl)borate

    $591.00/5g

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    1-Deoxy-1-morpholino-D-fructose

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    A3201956291-16-398%

    1-Deoxy-1-morpholino-D-fructose

    $65.00/100mg

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    2-Morpholinopyrimidin-4-amine

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    A50054318215-94-697%

    2-Morpholinopyrimidin-4-amine

    $332.00/250mg

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    4-(6-Chloropyridazin-3-yl)morpholine

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    A21343617259-32-498%

    4-(6-Chloropyridazin-3-yl)morpholine

    $80.00/5g

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    (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate

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    A124997174649-09-397%

    (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate

    $6.00/1g

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    5-LOX-IN-1

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    A122975055040-82-998%

    5-LOX-IN-1

    $108.00/5mg

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    (R)-Morpholin-2-ylmethanol

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    A511736156925-22-398%

    (R)-Morpholin-2-ylmethanol

    $30.00/1g

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    (R)-2-Isopropylmorpholine

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    A632601792886-64-798%

    (R)-2-Isopropylmorpholine

    $25.00/250mg

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    2-Morpholinophenol

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    A13028441536-44-195%

    2-Morpholinophenol

    $64.00/250mg

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    4-(4-Bromo-2-methylphenyl)morpholine

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    A3013101279032-06-297%

    4-(4-Bromo-2-methylphenyl)morpholine

    $143.00/1g

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    tert-Butyl ((4-benzylmorpholin-2-yl)methyl)carbamate

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    A1363219146944-34-597%

    tert-Butyl ((4-benzylmorpholin-2-yl)methyl)carbamate

    $237.00/250mg

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    (4-Benzylmorpholin-2-yl)methanol

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    A66681940987-24-498%

    (4-Benzylmorpholin-2-yl)methanol

    $23.00/1g

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    4-Boc-2-Hydroxymethylmorpholine

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    A161560135065-69-998%

    4-Boc-2-Hydroxymethylmorpholine

    $20.00/5g

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    CB65

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    A380551913534-05-198%

    CB65

    $51.00/10mg

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    4-Oxa-7-azaspiro[2.5]octan-6-one

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    A7335641253790-21-498%

    4-Oxa-7-azaspiro[2.5]octan-6-one

    $221.00/250mg

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