Chemistry
Heterocyclic Building Blocks
Morpholines
The chemical formula of morpholine is O(CH2CH2)2NH, which contains both amine and ether functional groups, making it an organic heterocycle.
Morpholine, a colorless liquid with a fishy odor, possesses a flash point of 100°F and can corrode tissue. It is less dense than water and can dissolve in water, while its vapors are denser than air.
Organic synthesis extensively employs morpholine, which serves as a fundamental component in manufacturing various compounds such as the antibiotic linezolid, the anticancer drug gefitinib (Iressa), and the analgesic dextromoramide.
Morpholine serves as a solvent for various organic compounds, including resins, dyes, and waxes. In organic synthesis, morpholine-based enamines have broad applications in the formation of C-C and C-X bonds.
Several pharmaceuticals, such as antibiotics, anticancer agents, and analgesics, are prepared using morpholines.
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2-Morpholino-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-1-yl)ethanone
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2-Morpholino-N-(4-phenylthiazol-2-yl)acetamide
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4-(Morpholinomethyl)-1H-pyrrole-2-carbaldehyde
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4-[(Morpholin-4-yl)sulphonyl]benzeneboronic acid
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4-(5-Bromo-1,3,4-thiadiazol-2-yl)morpholine
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tert-Butyl ((4-benzylmorpholin-2-yl)methyl)carbamate
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(S)-tert-Butyl 2-(bromomethyl)morpholine-4-carboxylate
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(S)-4-(tert-Butoxycarbonyl)-3-methylmorpholine-3-carboxylic acid
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4,4'-((3-Nitrophenyl)methylene)dimorpholine