Chemistry Heterocyclic Building Blocks Piperazines

Piperazines

Piperazine is a type of organic compound characterized by a six-membered ring that contains two nitrogen atoms located at opposite positions within the ring. It appears in the form of tiny deliquescent crystals with an alkaline nature and a salty flavor.

Piperazine dissolves readily in water and ethylene glycol but does not dissolve in diethyl ether. It exhibits weak basicity with two pKb values of 5.35 and 9.73 at 25 °C. A 10% aqueous solution of piperazine has a pH range of 10.8-11.8.

Although piperazine has an extraordinary ability to dissolve uric acid and create a soluble urate outside of the body, its effectiveness in clinical settings has not been as impressive.

Piperazine, which is also known as hexahydropyrazine, is an anthelmintic medication that is utilized to treat intestinal roundworm infections in both humans and domestic animals (including poultry). It is also effective against pinworm infections in humans.

In 1953, Piperazine was initially presented as an anthelmintic. Its anthelmintic effect typically involves the paralysis of parasites, which enables the host body to expel or remove the invading organism with ease.

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By Key Group+−

benzothiophene-piperazine benzylpiperazine boc-piperazine butylpiperazine cyanopiperazine dimethylpiperazine dioxaborolane-piperazine ethylpiperazine formylpiperazine hydroxyethyl-piperazine hydroxymethyl-piperazine-carboxylate indazo-piperazine isobutylpiperazine isopropylpiperazine methylpiperazine oxopiperazine phenylpiperazine piperazin-amine piperazin-pyrimidin piperazine-carboxylate piperazine-carboxylic-acid piperazine-hydrochloride piperazine-hydroxyl piperazine-methanol piperazine-pyrazine piperazine-pyridine piperazine-quinoline propylpiperazine pyrazol-piperazine sulfonyl-piperazine trifluoromethyl-phenyl-piperazin trifluoromethyl-piperazine trimethylpiperazine

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Dioxolanes Furans Imidazoles Imidazolines Indazoles Indoles Morpholines Non-Halogenated Heterocycles Other Aromatic Heterocycles Oxetanes Phthalazines Piperidines Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Quinazolines Quinolines Spiroes Tetrahydrofurans Thiazoles Triazoles

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Alcohols Aldehydes Alkenyls Alkyls Alkynyls Amides Amines Aryls Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Ketones Nitriles Nitroes Organoboron Phenols Sulfamides Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

Framework+−

(9H-fluoren-9-yl)methyl piperazine-1-carboxylate (R)-2-benzylpiperazine 1,4-diphenylpiperazine 1-(2-chlorophenyl)piperazine 1-(2-fluorophenyl)piperazine 1-(3-methoxyphenyl)piperazine 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine 1-(methylsulfonyl)piperazine 1-(phenylsulfonyl)piperazine 1-(piperidin-4-yl)piperazine 1-(pyridin-3-yl)piperazine 1-(pyridin-3-ylmethyl)piperazine 1-benzhydryl-4-benzylpiperazine 1-benzhydrylpiperazine 1-benzyl 4-(tert-butyl) piperazine-1,4-dicarboxylate 1-benzyl-4-methylpiperazine 1-ethyl-4-phenylpiperazine 1-ethylpiperazine 1-isopropylpiperazine 1-methyl-4-(pyridin-2-yl)piperazine 1-methyl-4-phenylpiperazine 1-methylpiperazin-2-one 1-methylpiperazine 10-(3-(piperazin-1-yl)propyl)-10H-phenothiazine 2-(4-(benzyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(piperazin-1-yl)benzonitrile 2-(piperazin-1-yl)ethan-1-amine 2-(piperazin-1-yl)ethan-1-ol 2-(piperazin-1-yl)pyrazine 2-(piperazin-1-yl)pyrimidine 2-phenylpiperazine 3-(piperazin-1-yl)aniline 3-(piperazin-1-yl)benzoic acid 3-(piperazin-1-yl)pyridazine 3-methylpiperazin-2-one 4-(piperazin-1-yl)benzaldehyde 4-(piperazin-1-yl)pyrimidine benzyl 2-methylpiperazine-1-carboxylate benzyl 3-(hydroxymethyl)piperazine-1-carboxylate benzyl 3-methylpiperazine-1-carboxylate phenyl(piperazin-1-yl)methanone piperazine-2,5-dione tert-butyl 3-oxopiperazine-1-carboxylate tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-benzylpiperazine-1-carboxylate tert-butyl 4-phenylpiperazine-1-carboxylate tert-butyl piperazine-1-carboxylate

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    1-(6-Nitropyridin-3-yl)piperazine

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    A100484775288-71-695%

    1-(6-Nitropyridin-3-yl)piperazine

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    1-((2-(Trifluoromethyl)phenyl)sulfonyl)piperazine

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    1-((2-(Trifluoromethyl)phenyl)sulfonyl)piperazine

    $247.00/1g

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    4,4'-(Piperazine-1,4-diyl)dianiline

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    A11931607479-12-198%

    4,4'-(Piperazine-1,4-diyl)dianiline

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    3-(1-Piperazinyl)-1,2-benzisothiazole

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    A13954587691-87-095%

    3-(1-Piperazinyl)-1,2-benzisothiazole

    $5.00/1g

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    tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

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    tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

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    2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

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    A158305761440-75-995%

    2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

    $95.00/10g

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    4,7-Diazaspiro[2.5]octane dihydrochloride

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    A164210145122-56-197%

    4,7-Diazaspiro[2.5]octane dihydrochloride

    $488.00/5g

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    Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

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    A184318105404-65-795%

    Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

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    tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

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    A196536571189-16-797%

    tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

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    4-Boc-4,7-diazaspiro[2.5]octane

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    A221123674792-08-697%

    4-Boc-4,7-diazaspiro[2.5]octane

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    4-((4-Methylpiperazin-1-yl)methyl)benzoic acid

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    4-((4-Methylpiperazin-1-yl)methyl)benzoic acid

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    tert-Butyl piperazine-1-carboxylate

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    tert-Butyl piperazine-1-carboxylate

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    1-(2-((2,4-Dimethylphenyl)sulfinyl)phenyl)piperazine

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    A4026411429908-35-997%

    1-(2-((2,4-Dimethylphenyl)sulfinyl)phenyl)piperazine

    $156.00/100mg

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    (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine

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    A416464300543-56-095%

    (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine

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    4,4'-(Piperazine-1,4-diyl)dibenzaldehyde

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    A46130110159-39-495%

    4,4'-(Piperazine-1,4-diyl)dibenzaldehyde

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    1-Methyl-4-(piperidin-4-yl)piperazine

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    1-Methyl-4-(piperidin-4-yl)piperazine

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    4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride

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    A517625106261-49-898%

    4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride

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    2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride

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    2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride

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    4-((4-Methylpiperazin-1-yl)methyl)benzonitrile

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    A597068125743-63-797%

    4-((4-Methylpiperazin-1-yl)methyl)benzonitrile

    $96.00/1g

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    4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride

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    A63057455112-42-095%

    4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride

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