Home Chemistry Heterocyclic Building Blocks Pyridines 4-Bromo-2-Methoxypyridine
Nucleophilic substitution reactions: The bromine atom can be substituted by various nucleophiles such as amines, thiols, or organometallic reagents.
Suzuki-Miyaura coupling: 4-Bromo-2-methoxypyridine can undergo cross-coupling reactions with boronic acids or boronate esters in the presence of a palladium catalyst to form biaryl compounds.
Heck reaction: It can participate in Heck coupling reactions with olefins in the presence of a palladium catalyst to form substituted pyridines.
Sonogashira coupling: 4-Bromo-2-methoxypyridine can undergo coupling reactions with terminal alkynes in the presence of a palladium catalyst to form alkynylated pyridine derivatives.
Reduction reactions: The bromine atom can be reduced to a variety of functional groups such as alkyl groups or hydrogen.
Electrophilic aromatic substitution: The methoxy group can be substituted under certain conditions to introduce various functional groups onto the pyridine ring.
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