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Chemical Structure| 2068806-31-3 Chemical Structure| 2068806-31-3

Structure of EGFR-IN-99
CAS No.: 2068806-31-3

Chemical Structure| 2068806-31-3

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EGFR-IN-99 is an effective inhibitor of EGFR and HER2 exon 20 insertions, showing excellent antiproliferative activity against DFCI127 cells with an EC50 of 11.5 nM, widely used in non-small cell lung cancer research.

Synonyms: JBJ-03-142-02

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of EGFR-IN-99

CAS No. :2068806-31-3
Formula : C25H22FN7O3
M.W : 487.49
SMILES Code : O=C(OCC1=CC=C(F)C=C1)N(C2=CC=CC(NC(C=C)=O)=C2)C3=NC(NC4=CN(C)N=C4)=NC=C3
Synonyms :
JBJ-03-142-02
English Name :4-Fluorobenzyl (3-acrylamidophenyl)(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)carbamate
MDL No. :N/A

Safety of EGFR-IN-99

Related Pathways of EGFR-IN-99

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
EGFR-IN-99 effectively inhibits EGFR and HER2 Exon 20 insertion mutants, demonstrating strong antiproliferative effects on DFCI127 cells with an EC50 of 11.5 nM. It is suitable for non-small cell lung cancer (NSCLC)[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.21mL

10.26mL

2.05mL

1.03mL

20.51mL

4.10mL

2.05mL

 

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