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Chemical Structure| 2068806-31-3 Chemical Structure| 2068806-31-3

Structure of EGFR-IN-99
CAS No.: 2068806-31-3

Chemical Structure| 2068806-31-3

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EGFR-IN-99 is an effective inhibitor of EGFR and HER2 exon 20 insertions, showing excellent antiproliferative activity against DFCI127 cells with an EC50 of 11.5 nM, widely used in non-small cell lung cancer research.

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Product Details of EGFR-IN-99

CAS No. :2068806-31-3
Formula : C25H22FN7O3
M.W : 487.49
SMILES Code : O=C(OCC1=CC=C(F)C=C1)N(C2=CC=CC(NC(C=C)=O)=C2)C3=NC(NC4=CN(C)N=C4)=NC=C3
MDL No. :N/A

Safety of EGFR-IN-99

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
EGFR-IN-99 effectively inhibits EGFR and HER2 Exon 20 insertion mutants, demonstrating strong antiproliferative effects on DFCI127 cells with an EC50 of 11.5 nM. It is suitable for non-small cell lung cancer (NSCLC)[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.21mL

10.26mL

2.05mL

1.03mL

20.51mL

4.10mL

2.05mL

 

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