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Chemical Structure| 2923115-93-7 Chemical Structure| 2923115-93-7

Structure of 2923115-93-7

Chemical Structure| 2923115-93-7

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Product Details of [ 2923115-93-7 ]

CAS No. :2923115-93-7
Formula : C63H94N5O9P
M.W : 1096.42
SMILES Code : C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCCCCCCCCCCCCCCCCCCCCC)[C@@H](O1)N2C(=O)N=C(NC(C)=O)C=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
English Name :(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(docosyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
MDL No. :N/A

Safety of [ 2923115-93-7 ]

Application In Synthesis of [ 2923115-93-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2923115-93-7 ]

[ 2923115-93-7 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 661-19-8 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: diethylene glycol dimethyl ether / 0.5 h / 100 °C / Inert atmosphere 2.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 3.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 50 °C / Inert atmosphere 4.1: pyridine; triethylamine / 20 °C / Inert atmosphere 5.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 5.2: 0.67 h / 0 °C 6.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 7 steps 1.1: diethylene glycol dimethyl ether / 0.5 h / 100 °C / Inert atmosphere 2.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 3.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 °C / Inert atmosphere 4.1: pyridine; triethylamine / 20 °C / Inert atmosphere 5.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 5.2: 0.67 h / 0 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 2
  • [ CAS Unavailable ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 50 °C / Inert atmosphere 3.1: pyridine; triethylamine / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 4.2: 0.67 h / 0 °C 5.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 6 steps 1.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 °C / Inert atmosphere 3.1: pyridine; triethylamine / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 4.2: 0.67 h / 0 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 3
  • [ 175013-46-4 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 50 °C / Inert atmosphere 3.1: pyridine; triethylamine / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 4.2: 0.67 h / 0 °C 5.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 6 steps 1.1: diethylene glycol dimethyl ether / 48 h / 145 °C / Inert atmosphere 2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 °C / Inert atmosphere 3.1: pyridine; triethylamine / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 4.2: 0.67 h / 0 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 4
  • [ 2923115-79-9 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 50 °C / Inert atmosphere 2.1: pyridine; triethylamine / 20 °C / Inert atmosphere 3.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 3.2: 0.67 h / 0 °C 4.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 5 steps 1.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 °C / Inert atmosphere 2.1: pyridine; triethylamine / 20 °C / Inert atmosphere 3.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 3.2: 0.67 h / 0 °C / Inert atmosphere 4.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 5
  • [ 2923115-82-4 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: pyridine; triethylamine / 20 °C / Inert atmosphere 2.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 2.2: 0.67 h / 0 °C 3.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 4 steps 1.1: pyridine; triethylamine / 20 °C / Inert atmosphere 2.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 2.2: 0.67 h / 0 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 6
  • [ 2923115-84-6 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 1.2: 0.67 h / 0 °C 2.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
Multi-step reaction with 3 steps 1.1: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C / Inert atmosphere 1.2: 0.67 h / 0 °C / Inert atmosphere 2.1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
  • 7
  • [ 89992-70-1 ]
  • [ 2923115-91-5 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
90% With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 14h; Inert atmosphere; 1 Compound 114: DIPEA (0.16 mL, 0.9 mmol) followed by 2-cyanoethyl N,N-diisopropylchlorophosphoramidite (0.20 mL, 0.9 mmol) were added to a solution of compound 113 (0.63 g, 0.7 mmol) in anhyd. DCM (5 mL) under Ar. The mixture was stirred at rt for 14 h, cooled to 0° C., quenched by addition of sat. NaHCO3 and extracted with AcOEt (15 mL). Organic phase was separated, washed with sat. NaCl, and dried over anhyd. sodium sulfate. Crude material (0.82 g) was purified over a standard 24 g flash column of silica gel that was eluted with isocratic 70% of AcOEt containing 0.3% of TEA in hexanes followed by gradient 70 to 100% of AcOEt containing 0.3% of TEA in hexanes to afford 0.69 g (90%) of 114 as a white foam. 1H NMR (600 MHz, DMSO) δ 10.94 (s, 1H), 8.46-8.34 (m, 1H), 7.46-7.36 (m, 2H), 7.36-7.20 (m, 7H), 6.98 (t, J=8.4 Hz, 1H), 6.89 (t, J=8.6 Hz, 4H), 5.85 (d, J=13.8 Hz, 1H), 4.55-4.34 (m, 1H), 4.20-4.11 (m, 1H), 4.06-3.83 (m, 2H), 3.75 (s, 3H), 3.74 (s, 3H), 3.68-3.64 (m, 1H), 3.50-3.44 (m, 2H), 2.77-2.69 (m, 1H), 2.66-2.59 (m, 1H), 2.10 (s, 3H), 1.56-1.49 (m, 2H), 1.26-1.16 (m, 51H), 0.96 (d, J=6.7 Hz, 3H), 0.85-0.82 (m, 3H). P31 NMR (243 MHz, DMSO) δ 149.23, 147.94.
90% With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 14h; Inert atmosphere; 1 Compound 114: DIPEA (0.16 mL, 0.9 mmol) followed by 2-cyanoethyl N,N- diisopropylchlorophosphoramidite (0.20 mL, 0.9 mmol) were added to a solution of compound 113 (0.63 g, 0.7 mmol) in anhydrousDCM (5 mL) under Ar. The mixture was stirred at room temprature for 14 hours, cooled to 0 °C, quenched by addition of saturated NaHCO3and extracted with AcOEt (15 mL). Organic phase was separated, washed with saturated NaCl, and dried over anhydrous sodium sulfate. Crude material (0.82 g) was purified over a standard 24 g flash column of silica gel that was eluted with isocratic 70% of AcOEt containing 0.3% of TEA in hexanes followed by gradient 70 to 100% of AcOEt containing 0.3% of TEA in hexanes to afford 0.69 g (90%) of 114 as a white foam.1H NMR (600 MHz, DMSO) δ 10.94 (s, 1H), 8.46 - 8.34 (m, 1H), 7.46 - 7.36 (m, 2H), 7.36 - 7.20 (m, 7H), 6.98 (t, J = 8.4 Hz, 1H), 6.89 (t, J = 8.6 Hz, 4H), 5.85 (d, J = 13.8 Hz, 1H), 4.55 - 4.34 (m, 1H), 4.20 - 4.11 (m, 1H), 4.06 - 3.83 (m, 2H), 3.75 (s, 3H), 3.74 (s, 3H), 3.68 - 3.64 (m, 1H), 3.50 - 3.44 (m, 2H), 2.77 - 2.69 (m, 1H), 2.66 - 2.59 (m, 1H), 2.10 (s, 3H), 1.56 - 1.49 (m, 2H), 1.26 - 1.16 (m, 51H), 0.96 (d, J = 6.7 Hz, 3H), 0.85 - 0.82 (m, 3H). P31 NMR (243 MHz, DMSO) δ 149.23, 147.94.
  • 8
  • [ 2923115-89-1 ]
  • [ 2923115-93-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere
 

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