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Chemical Structure| 35761-83-2 Chemical Structure| 35761-83-2

Structure of 35761-83-2

Chemical Structure| 35761-83-2

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Product Details of [ 35761-83-2 ]

CAS No. :35761-83-2
Formula : C4H7IO
M.W : 198.00
SMILES Code : C/C(I)=C/CO
English Name :(Z)-3-Iodobut-2-en-1-ol
MDL No. :MFCD31735576

Safety of [ 35761-83-2 ]

Application In Synthesis of [ 35761-83-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35761-83-2 ]

[ 35761-83-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 459423-19-9 ]
  • [ 35761-83-2 ]
  • [ 623175-72-4 ]
YieldReaction ConditionsOperation in experiment
91% With sodium carbonate In methanol; water; toluene at 100℃; B A solution of 3,3-dimethyl-2,3-dihydro-benzofuran-5-boronic acid (Intermediate 3, 0.55 g, 2.86 mmol) and 3-iodo-but-2 (Z)-ene-ol (0.56 g, 2.86 mmol) in a mixture of methanol (4 mL), toluene (10 mL) and water (2 mL) was treated with sodium carbonate (0.6 g, 5.72 mmol) and tetrakis(triphenylphosphine)palladium(0)(85 mg), sparged with argon for 5 minutes and heated at 100° C. overnight. The reaction mixture was cooled to ambient temperature, the volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ether. The combined organic extract was dried over anhydrous sodium sulfate and evaporated in vacuo to an oily residue which was purified by flash column chromatography over silica gel (230-400 mesh) using 22% ethyl acetate in hexane as the eluent to provide 0.57 g, 91% of the title compound as a brown oil.
 

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