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Chemical Structure| 3031477-68-3 Chemical Structure| 3031477-68-3

Structure of 3031477-68-3

Chemical Structure| 3031477-68-3

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Product Details of [ 3031477-68-3 ]

CAS No. :3031477-68-3
Formula : C24H26N2O2
M.W : 374.48
SMILES Code : O=[N+](C1=CC=CC=C1NC2=C(C(C)C)C=C(C3=CC=CC=C3)C=C2C(C)C)[O-]
English Name :3,5-Diisopropyl-N-(2-nitrophenyl)-[1,1'-biphenyl]-4-amine
MDL No. :N/A

Safety of [ 3031477-68-3 ]

Application In Synthesis of [ 3031477-68-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3031477-68-3 ]

[ 3031477-68-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 609-73-4 ]
  • [ 389104-62-5 ]
  • [ 3031477-68-3 ]
YieldReaction ConditionsOperation in experiment
82 % With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In toluene at 90℃; Inert atmosphere; Add 3,5-diisopropyl-1,1'-biphenyl 4-amine (7.8g, 29.3mmol),1-iodo-2-nitrobenzene (8.75g, 35.1mmol),Cs2CO3(23.85g, 73.2mmol)and toluene (220 mL).Degas the solution by purging with nitrogen for 20 minutes.Add SPhos (1.202g, 2.93mmol)and Pd2dba3 (1.341g, 1.464mmol),And the solution was degassed for another 10 minutes.The reaction flask was placed in a preheated oil bath at 90°C and stirred overnight using a magnetic stirrer.Add water (75mL),And transfer the mixture to a separatory funnel.Separate the organic layer and aqueous layer,And the organic layer was washed with water (2×75 mL).The organic layer was dried over anhydrous sodium sulfate.Filter and concentrate under reduced pressure.Using Teledyne ISCO automated fast chromatography system (330g silica gel column),The crude product was purified using 10% ethyl acetate in heptane as eluent.The pure fractions were combined and concentrated under reduced pressure.The desired product is obtained as a yellow solid(9g, yield 82%, LCMS purity 98.5%).
 

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