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Chemical Structure| 3092880-60-6 Chemical Structure| 3092880-60-6

Structure of 3092880-60-6

Chemical Structure| 3092880-60-6

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Product Details of [ 3092880-60-6 ]

CAS No. :3092880-60-6
Formula : C7H4BrIN2
M.W : 322.93
SMILES Code : BrC1=CC=C2NN=CC2=C1I
English Name :5-Bromo-4-iodo-1H-indazole
MDL No. :N/A

Safety of [ 3092880-60-6 ]

Application In Synthesis of [ 3092880-60-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3092880-60-6 ]

[ 3092880-60-6 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 172681-47-9 ]
  • [ 3092880-60-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 25 °C 2: sodium nitrite; acetic acid / water / 2 h / 0 - 20 °C
  • 2
  • [ 2091513-17-4 ]
  • [ 3092880-60-6 ]
YieldReaction ConditionsOperation in experiment
67.1% With acetic acid; sodium nitrite In water at 0 - 20℃; for 2h; s.2 Step2:int-22-3 Toasolutionofint-22-2(85.0g,272.0mmol)inAcOH(850mL))wasaddedasolutionofsodium nitrite(22.56g,327mmol)inwater(136mL)dropwiseat0.Theresultingreactionwasstirredat20for2hrs.Thereactionmixturewasconcentrated,dilutedwithwater(1.5L)andadjustedpHto8withNa2CO3.ThemixturewasextractedwithEtOAc(1L×3).Thecombinedorganiclayerswerewashedwithbrine(1L),driedoverNa2SO4,filtered,concentratedandpurifiedbycolumnchromatographytoaffordint-22-3(59.0g,183.0mmol,67.1%yield).LCMS:323.0[M+H]+.
  • 3
  • [ 3092880-60-6 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
  • 4
  • [ 3092880-60-6 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 3.1: (R,R)-1,2-bis(N-methylamino)cyclohexane; potassium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Inert atmosphere
  • 5
  • [ 3092880-60-6 ]
  • [ 3092880-63-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 3.1: (R,R)-1,2-bis(N-methylamino)cyclohexane; potassium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Inert atmosphere 4.1: palladium(II) hydroxide; hydrogen; 10% Pd/C / tetrahydrofuran / 6 h / 30 °C / 775.74 Torr
  • 6
  • [ 3092880-60-6 ]
  • [ 3092880-64-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 3.1: (R,R)-1,2-bis(N-methylamino)cyclohexane; potassium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Inert atmosphere 4.1: palladium(II) hydroxide; hydrogen; 10% Pd/C / tetrahydrofuran / 6 h / 30 °C / 775.74 Torr 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 25 °C
  • 7
  • [ 3092880-60-6 ]
  • [ 3092880-65-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 3.1: (R,R)-1,2-bis(N-methylamino)cyclohexane; potassium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Inert atmosphere 4.1: palladium(II) hydroxide; hydrogen; 10% Pd/C / tetrahydrofuran / 6 h / 30 °C / 775.74 Torr 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 25 °C 6.1: DIAD; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere
  • 8
  • [ 3092880-60-6 ]
  • [ 3092880-66-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 1.5 h / 0 - 20 °C 2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 3.1: (R,R)-1,2-bis(N-methylamino)cyclohexane; potassium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Inert atmosphere 4.1: palladium(II) hydroxide; hydrogen; 10% Pd/C / tetrahydrofuran / 6 h / 30 °C / 775.74 Torr 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 25 °C 6.1: DIAD; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere 7.1: hydrogenchloride / 1,4-dioxane / 1 h / 25 °C
 

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