Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	2765625-93-0
Formula :	C₂₀H₁₄F₃N₃O₇S
M.W :	497.40
SMILES Code :	O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O
English Name :	N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
MDL No. :	N/A
InChI Key :	RKAFYSIKAVFVPS-UHFFFAOYSA-N
Pubchem ID :	155925914

GHS Pictogram:
Signal Word:
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Yield	Reaction Conditions	Operation in experiment
68%	In pyridine at 80℃; for 16h; Inert atmosphere;
44%	With pyridine at 80℃; for 12h;	7.A Step A. Preparation of Compound IG-9 Compound IG-9 A mixture of 5-amino-2-(26-dioxopiperidin-3-yl)isoindoline-1,3-dione (500 mg, 1.83 mmol, 100 eq) and 2-(trifluoromethoxy)benzene-1-sulfonyl chloride (954 mg, 3.66 mmol, 2.00 eq) in pyridine (8 mL) was stirred at 80 °C for 12 h. The mixture was concentrated to give a residue. The residue was purified by Prep-HPLC (column: Phenomenex luna C18 15025mm10um; mobile phase: [water(FA)-ACN]; B%: 36%-66%, 10 min) and lyophilized to afford N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide, Compound IG-9, (409.01 mg, 814 umol, 44% yield, 99% purity) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) 11.60 (s, 1H), 11.10 (s, 1H), 8.10 (dd, J=1.6, 8.0 Hz, 1H), 7.91-7.76 (m, 2H), 7.70-7.56 (m, 2H), 7.55-7.46 (m, 2H), 5.09 (dd, J=5.6, 12.8 Hz, 1H), 2.93-2.80 (m, 1H), 2.60 (br d, J=2.4 Hz, 1H), 2.43 (br d, J=4.4 Hz, 1H), 2.07-1.96 (m, 1H) MS (ESI) m/z 498.2 [M-H]+
	With pyridine at 80℃; for 16h; Inert atmosphere;	3 GENERAL PROCEDURE FOR THE SYNTHESIS OF SULFONAMIDES. General procedure: In a 48 position Mettler Toledo XT reaction block containing 11 .5 x 110 mm test tubes equipped with a stir bar was added 0.1 mmol of 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1 , 3-dione and the corresponding sulfonyl chloride (2.0 equiv, 0.2 mmol) for compounds 1-37 and 94-103, whereas 0.075 mmol of 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1 , 3-dione and the corresponding sulfonyl chloride (2.0 equiv, 0.15 mmol) for compounds 38-93 (see Table 2 immediately following the Examples below). Anhydrous pyridine (500 uL) was added and the reactions were heated in a reaction block to 80 °C and stirred overnight under nitrogen. The reactions were checked by LIPLC the next morning, concentrated to dryness and diluted with 1 mL of DMSO. Pre-purification analysis in the LIPLC was done with water/acetonitrile/0.1% formic acid. Library purification was performed on the Waters purification/analytical LC/UV/ELSD system and parallel evaporations were carried out using a Genevac HT-24. Exemplary compounds 1-2, 5, 7, and 20 were obtained using methods described below, and shown in the general synthesis scheme above. The specific reaction sequence for each of the compounds 1-2, 5, 7, and 20 is shown preceding the characterization data for the compound immediately below. Additional characterization data for compounds 1- 103 is shown in Table 2 immediately following the Examples below.

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CAS No.: 2765625-93-0

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CAS No.: 2765625-93-0

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[ 2765625-93-0 ] Synthesis Path-Downstream 1~1

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed