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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 104987-12-4 Chemical Structure| 104987-12-4

Structure of Ascomycin
CAS No.: 104987-12-4

Chemical Structure| 104987-12-4

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Ascomycin is a naturally occuring macrolide produced by the fermentation of Streptomyces hygroscopicus and an ethyl analog of tacrolimus (FK506), exhibiting strong immunosuppressant properties.

Synonyms: FK520; FR-900520; Immunomycin. Ascomycin

4.5 *For Research Use Only !

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Product Details of Ascomycin

CAS No. :104987-12-4
Formula : C43H69NO12
M.W : 792.01
SMILES Code : O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
Synonyms :
FK520; FR-900520; Immunomycin. Ascomycin
MDL No. :MFCD06198665

Safety of Ascomycin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
293T cells 1 μM To study the competitive binding of Ascomycin and Rapamycin to FKBP12, results showed that increasing the concentration of ascomycin led to a reduction in hRLUC activity, indicating that ascomycin blocked the binding of rapamycin to FKBP12, thus reducing the heterodimerization with FRB. PMC3148280

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice T cell-dependent response model Intraperitoneal injection 4 mg/kg Single dose, 12 hours duration To assess the immunosuppressive activity of JH-FK-05 in vivo, results showed that JH-FK-05 at 60 mg/kg did not exhibit immunosuppressive activity. PMC9239059

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00231998 Atopic Dermatitis Phase 3 Completed - Japan ... More >> This study is not being conducted in the United States Various Cities, Japan Less <<
NCT00232011 Atopic Dermatitis Phase 3 Completed - Japan ... More >> This study is not being conducted in the United States Various Cities, Japan Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.26mL

0.25mL

0.13mL

6.31mL

1.26mL

0.63mL

12.63mL

2.53mL

1.26mL

References

 

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