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Chemical Structure| 163768-50-1 Chemical Structure| 163768-50-1

Structure of Auristatin F
CAS No.: 163768-50-1

Chemical Structure| 163768-50-1

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Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Auristatin F

CAS No. :163768-50-1
Formula : C40H67N5O8
M.W : 745.99
SMILES Code : CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)OC)C)=O)C(C)C)=O
English Name :(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(Dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid
MDL No. :MFCD25976745
InChI Key :LGNCNVVZCUVPOT-FUVGGWJZSA-N
Pubchem ID :67472795

Safety of Auristatin F

Related Pathways of Auristatin F

cytoskeleton

Isoform Comparison

Biological Activity

Description
Auristatin F, recognized for its significant cytotoxicity in antibody-linked therapies and as an MMAF analogue, acts as a potent disruptor of microtubules and a vascular damage agent (VDA). It halts cellular division by blocking the assembly of tubulin. Auristatin F is applicable in the creation of ADCs[1].[2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.70mL

1.34mL

0.67mL

13.41mL

2.68mL

1.34mL

References

 

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