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Chemical Structure| 384859-58-9 Chemical Structure| 384859-58-9

Structure of BCH001
CAS No.: 384859-58-9

Chemical Structure| 384859-58-9

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BCH001 is a quinoline-based PAPD5 inhibitor that can restore telomerase activity in stem cells affected by keratinization disorders. It has important applications in the study of keratinization disorders and related genetic diseases.

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Product Details of BCH001

CAS No. :384859-58-9
Formula : C20H15F3N2O5
M.W : 420.34
SMILES Code : O=C(C1=C(NC2=CC=CC=C2C(O)=O)C3=CC(OC(F)(F)F)=CC=C3N=C1)OCC
MDL No. :MFCD02932975
InChI Key :FWJMVZAVAUGMDX-UHFFFAOYSA-N
Pubchem ID :1043578

Safety of BCH001

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

Description
BCH001, a quinoline derivative, acts as a specific inhibitor of PAPD5. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. It exhibits no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is utilized for regulating aging [1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.90mL

2.38mL

1.19mL

23.79mL

4.76mL

2.38mL

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