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Chemical Structure| 292870-53-2 Chemical Structure| 292870-53-2

Structure of BV02
CAS No.: 292870-53-2

Chemical Structure| 292870-53-2

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BV02 is a potent 14-3-3 protein-protein interaction (PPI) inhibitor that shows cytotoxicity against imatinib-sensitive wild-type Bcr-Abl and IM-resistant T315I mutant hematopoietic cells, indicating its potential in studying chronic myeloid leukemia.

Synonyms: 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of BV02

CAS No. :292870-53-2
Formula : C20H15N3O5
M.W : 377.35
SMILES Code : O=C(C1=CC2=C(C(N(C3=C(C)N(C)N(C4=CC=CC=C4)C3=O)C2=O)=O)C=C1)O
Synonyms :
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid
English Name :2-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid
MDL No. :MFCD00356631

Safety of BV02

Related Pathways of BV02

epigenetics
DNA
RTK
PI3K-AKT
pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.27mL

13.25mL

2.65mL

1.33mL

26.50mL

5.30mL

2.65mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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