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Chemical Structure| 329198-87-0 Chemical Structure| 329198-87-0

Structure of C-178
CAS No.: 329198-87-0

Chemical Structure| 329198-87-0

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C-178 is a STING inhibitor that can block palmitoylation (PMA)-induced clustering of STING.

Synonyms: STING inhibitor C-178

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Product Details of C-178

CAS No. :329198-87-0
Formula : C17H10N2O5
M.W : 322.27
SMILES Code : O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2
Synonyms :
STING inhibitor C-178
MDL No. :MFCD01146392
InChI Key :URUVDCCYSJEGQQ-UHFFFAOYSA-N
Pubchem ID :2866412

Safety of C-178

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
C-178 functions as a powerful and specific covalent inhibitor targeting STING. It forms a bond with Cys91, effectively dampening STING reactions triggered by various authentic activators in mice but not in humans [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.10mL

0.62mL

0.31mL

15.51mL

3.10mL

1.55mL

31.03mL

6.21mL

3.10mL

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