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Chemical Structure| 2412270-22-3 Chemical Structure| 2412270-22-3

Structure of CA77.1
CAS No.: 2412270-22-3

Chemical Structure| 2412270-22-3

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CA77.1 is a brain-penetrant and orally active chaperone-mediated autophagy activator used to treat for Alzheimer's disease.

Synonyms: CA

4.5 *For Research Use Only !

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Product Details of CA77.1

CAS No. :2412270-22-3
Formula : C16H12ClN3O
M.W : 297.74
SMILES Code : CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
Synonyms :
CA
MDL No. :N/A
InChI Key :ZQXMPDVGBWOTBY-UHFFFAOYSA-N
Pubchem ID :146439211

Safety of CA77.1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
CA77.1 is a potent, brain-penetrant, and orally active activator of chaperone-mediated autophagy (CMA) with favorable pharmacokinetics. A derivative of AR7, CA77.1 enhances the expression of the lysosomal receptor LAMP2A in lysosomes. It ameliorates behavior and neuropathology in the PS19 mouse model, making it useful for Alzheimer's disease research[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.79mL

3.36mL

1.68mL

33.59mL

6.72mL

3.36mL

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