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Chemical Structure| 2412270-22-3 Chemical Structure| 2412270-22-3

Structure of CA77.1
CAS No.: 2412270-22-3

Chemical Structure| 2412270-22-3

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CA77.1 is a brain-penetrant and orally active chaperone-mediated autophagy activator used to treat for Alzheimer's disease.

Synonyms: CA

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of CA77.1

CAS No. :2412270-22-3
Formula : C16H12ClN3O
M.W : 297.74
SMILES Code : CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
Synonyms :
CA
English Name :N-(4-(6-Chloroquinoxalin-2-yl)phenyl)acetamide
MDL No. :N/A
InChI Key :ZQXMPDVGBWOTBY-UHFFFAOYSA-N
Pubchem ID :146439211

Safety of CA77.1

Isoform Comparison

Biological Activity

Description
CA77.1 is a potent, brain-penetrant, and orally active activator of chaperone-mediated autophagy (CMA) with favorable pharmacokinetics. A derivative of AR7, CA77.1 enhances the expression of the lysosomal receptor LAMP2A in lysosomes. It ameliorates behavior and neuropathology in the PS19 mouse model, making it useful for Alzheimer's disease research[1].

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.79mL

3.36mL

1.68mL

33.59mL

6.72mL

3.36mL

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