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Chemical Structure| 942947-93-5 Chemical Structure| 942947-93-5

Structure of CCT129202
CAS No.: 942947-93-5

Chemical Structure| 942947-93-5

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CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μM for Aurora A, Aurora B, and Aurora C, respectively.

Synonyms: CCT129202

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Product Details of CCT129202

CAS No. :942947-93-5
Formula : C23H25ClN8OS
M.W : 497.02
SMILES Code : O=C(NC1=NC=CS1)CN2CCN(C3=C4C(NC(C5=CC=C(N(C)C)C=C5)=N4)=NC=C3Cl)CC2
Synonyms :
CCT129202
MDL No. :MFCD18074522

Safety of CCT129202

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of CCT129202

epigenetics
DNA

Isoform Comparison

Biological Activity

Target
  • Aurora A

    Aurora A, IC50:42 nM

  • Aurora B

    Aurora B, IC50:198 nM

  • Aurora C

    Aurora C, IC50:227 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Human diploid fibroblasts (HDFs) 0.5, 1, 5, 10, 20 μM 1 day To evaluate the cytotoxicity of CCT129202 in senescent and non-senescent HDFs. Results showed non-selective cytotoxicity in both senescent and non-senescent cells. PMC7244031

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.06mL

2.01mL

1.01mL

20.12mL

4.02mL

2.01mL

References

 

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