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Chemical Structure| 202284-84-2 Chemical Structure| 202284-84-2

Structure of 202284-84-2

Chemical Structure| 202284-84-2

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Product Details of [ 202284-84-2 ]

CAS No. :202284-84-2
Formula : C37H49N4O7P
M.W : 692.78
SMILES Code : CC(N(C(C)C)P(OCC(C(NC)=O)(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)C(NC)=O)OCCC#N)C
English Name :2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(methylamino)-2-(methylcarbamoyl)-3-oxopropyl (2-cyanoethyl) diisopropylphosphoramidite
MDL No. :MFCD35066683

Safety of [ 202284-84-2 ]

Application In Synthesis of [ 202284-84-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202284-84-2 ]

[ 202284-84-2 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 40615-36-9 ]
  • [ 1334145-19-5 ]
  • [ 202284-84-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: pyridine; dmap / 0 - 24 °C 2.1: 1-methyl-1H-imidazole; 1H-tetrazole / dichloromethane / 24 °C 2.2: 2 h / 0 - 24 °C
  • 2
  • [ 102691-36-1 ]
  • [ 202284-83-1 ]
  • [ 202284-84-2 ]
YieldReaction ConditionsOperation in experiment
75 % Stage #1: C28H32N2O6 With 1-methyl-1H-imidazole; 1H-tetrazole In dichloromethane at 24℃; Stage #2: N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite In dichloromethane at 0 - 24℃; 1.5-2.5 (5) At room temperature at 24 °C, under magnetic stirring, compound 4 (3g, 6.10mmol) was dissolved in 24mL of dried DCM (dichloromethane), and nitrogen was replaced by 1-H tetrazole (344mg, 4.88mmol) and N-methylimidazole (125mg, 1.52mmol). The obtained mixed system was cooled to 0 °C, and bis(diisopropylamino)(2-cyanoethoxy)phosphine (3.03g,10.06mmol) dissolved in 6mLDCM was added dropwise, and the room temperature reaction was resumed after dropwise addition for 2h. Using HPLC detection (results shown in Figure 7), the raw material conversion was complete. In the drying reaction system at room temperature, n-heptane (30mL) was recrystallized to obtain compound 5 white powder (2.25g) in a yield of 75%. Hydrogen spectroscopy NMR was confirmed as target compound 5 (hydrogen spectroscopy NMR results are shown in Figure 8).
  • 3
  • [ 20605-01-0 ]
  • [ 202284-84-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: toluene / 110 °C / Inert atmosphere 2.1: water / 24 °C 3.1: hydrogenchloride / 1,4-dioxane / 24 °C 4.1: pyridine; dmap / 0 - 24 °C 5.1: 1-methyl-1H-imidazole; 1H-tetrazole / dichloromethane / 24 °C 5.2: 2 h / 0 - 24 °C
Multi-step reaction with 5 steps 1.1: toluene / 110 °C / Inert atmosphere 2.1: water / 24 °C 3.1: hydrogenchloride / 1,4-dioxane / 24 °C 4.1: pyridine; dmap / 0 - 24 °C 5.1: 1-methyl-1H-imidazole; 1H-tetrazole / dichloromethane / 24 °C 5.2: 2 h / 0 - 24 °C
  • 4
  • [ 3035129-17-7 ]
  • [ 202284-84-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: hydrogenchloride / 1,4-dioxane / 24 °C 2.1: pyridine; dmap / 0 - 24 °C 3.1: 1-methyl-1H-imidazole; 1H-tetrazole / dichloromethane / 24 °C 3.2: 2 h / 0 - 24 °C
  • 5
  • [ 743452-78-0 ]
  • [ 202284-84-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: water / 24 °C 2.1: hydrogenchloride / 1,4-dioxane / 24 °C 3.1: pyridine; dmap / 0 - 24 °C 4.1: 1-methyl-1H-imidazole; 1H-tetrazole / dichloromethane / 24 °C 4.2: 2 h / 0 - 24 °C
  • 6
  • [ 202284-84-2 ]
  • [ CAS Unavailable ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With 5-(ethylthio)-1H-tetrazole In acetonitrile at 20℃; for 0.833333h; Inert atmosphere;
  • 7
  • [ 25152-95-8 ]
  • [ 202284-84-2 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With 5-(ethylthio)-1H-tetrazole In acetonitrile at 20℃; for 0.416667h; Sealed tube; Inert atmosphere;
  • 8
  • [ 25152-95-8 ]
  • [ 202284-84-2 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 5-(ethylthio)-1H-tetrazole / acetonitrile / 0.42 h / 20 °C / Sealed tube; Inert atmosphere 2: tert.-butylhydroperoxide / water / 4.5 h / -10 - 20 °C / Inert atmosphere
 

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