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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Cuminaldehyde, the major component of Cuminum cyminum, is a natural aldehyde with inhibitory effect on α-synuclein fibrillation and cytotoxicity.
Synonyms: 4-Isopropylbenzaldehyde; Cuminal; Cuminic aldehyde
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 122-03-2 |
Formula : | C10H12O |
M.W : | 148.20 |
SMILES Code : | O=CC1=CC=C(C(C)C)C=C1 |
Synonyms : |
4-Isopropylbenzaldehyde; Cuminal; Cuminic aldehyde
|
MDL No. : | MFCD00006953 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 243 3-(4-Isopropyl-benzylamino)-4-methoxy-N-phenyl-benzamide The title compound has been made using the procedure of Example 50, but using 3-amino-4-methoxy-N-phenyl benzamide and 4-isopropylbenzaldehyde as starting materials, which are commercially available from Aldrich; m.p. 174-176 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | In ethanol; at 80℃; for 2h; | General procedure: ZrO2-Al2O3 solid acid catalytic material was added to the stirred solution of O-phenylenediamines and different substituted aromatic aldehydes in a suitable solvent, and the resulting mixture was heated at a particular temperature and monitored by TLC. After the completion of the reaction, the reaction mixture was cooled and filtered and the residue was washed with ethanol to recover the solid acid catalyst. Filtrate was evaporated in vacuum to get the crude reaction product, which was then purified by silica-gel column chromatography using a suitable mobile phase to separate the desired product. The reaction products were characterized by melting point, 1H NMR and 13C NMR spectroscopy (Bruker, 400 MHz), LC-MS (Varian), and HPLC (Waters) techniques |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With silica supported phosphomolybdic acid; air; In dichloromethane; at 20℃; | General procedure: To a mixture of 2-aminophenol (or 2-aminothiophenol)(1mmol) and aryl aldehyde (1 mmol) in CH2Cl2 (5mL)PMA.SiO2 (113 mg) was added. The mixture was stirred atroom temperature and the reaction was monitored by TLC.After completion, the mixture was filtered and the catalystwas recovered after washing the residue with EtOAc (3×5mL). The filtrate was concentrated to afford a gummy mass. On the other hand, to obtain a pure benzothiazole, theresidue was dissolved in EtOH (10 mL) and the solution waspoured onto ice-cold water (20 mL) to furnish solid productwhich was filtered, washed with ice-cold water and subsequentlydried. The recovered catalyst was recycled threetimes without affecting the yield of the product. |