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CAS No. :	2259-96-3
Formula :	C₁₄H₁₆ClN₃O₄S₂
M.W :	389.88
SMILES Code :	O=S1(C2=CC(=C(C=C2NC(N1)C1CC2C=CC1C2)Cl)S(=O)(=O)N)=O
Synonyms :	Doburil
MDL No. :	MFCD00210192
InChI Key :	BOCUKUHCLICSIY-UHFFFAOYSA-N
Pubchem ID :	2910

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

HEK 293 cells	100 μM	30 s	To study the effect of CTZ on single-channel properties, results showed CTZ increased the mean open time and burst frequency	Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2943-7.
HEK 293 cells	50 μM		To study the effect of CTZ on AMPA receptor affinity, results showed CTZ decreased the EC50 value of AMPA by ∼8-fold	Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2943-7.
HEK 293 cells	100 μM	4 s	To study the potentiating effect of CTZ on AMPA currents, results showed CTZ increased the peak AMPA currents by 90-fold	Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2943-7.
primary hippocampal neurons	5 μM	48 h	Induced epileptiform activity, results showed that CTZ-treated neurons exhibited synchronized epileptiform burst discharges.	CNS Neurosci Ther. 2024 Apr;30(4):e14504.
Hippocampal microisland cultured neurons	500 μM		High concentration of CTZ almost completely abolished IPSCs.	Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13025-9.
Hippocampal microisland cultured neurons	30 μM		CTZ significantly inhibited the amplitude of IPSCs.	Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13025-9.
Hippocampal microisland cultured neurons	100 μM	60 seconds	CTZ reversibly inhibited GABA A receptor-mediated inhibitory postsynaptic currents (IPSCs) and GABA-induced membrane currents in a dose-dependent manner. Single-channel analysis showed that CTZ significantly reduced the open probability of GABA A receptor channels.	Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13025-9.
cultured superior colliculus neurones	3-300 μM		Cyclothiazide dramatically slowed desensitization of AMPA-induced currents and potentiated steady state currents (EC50 10.0±2.5 μM) to a much greater degree than peak currents. Both Ton and Toff were also increased by cyclothiazide in a concentration-dependent manner (EC50: Ton 42.1±4.5 μM; Toff 31.6±6.6 μM).	Br J Pharmacol. 1996 Mar;117(6):1209-21.
rat hippocampal synaptosomes	10μM	2 min	In the presence of cyclothiazide, AMPA elicited a dose-dependent increase in K+-stimulated [3H]-L-glutamate release but had no effect on basal release. This stimulation was blocked by CNQX and GYKI52466.	Br J Pharmacol. 1994 Oct;113(2):339-41.
bovine chromaffin cells	30-500 μM	2 s	To investigate the inhibitory effect of Cyclothiazide on neuronal-type nicotinic acetylcholine receptors (AChR) in bovine chromaffin cells. Results showed that Cyclothiazide dose-dependently inhibited the ACh-evoked peak current with little voltage-dependency.	Br J Pharmacol. 1995 Feb;114(3):648-55.
hippocampal neurons	5 μM	10 days	epileptiform activities were also observed after long-term low concentration CTZ treatment	J Physiol. 2006 Mar 15;571(Pt 3):605-18.
hippocampal neurons	20-50 μM	1-2 h	high concentration CTZ effectively elicited epileptiform activities after short-term treatment	J Physiol. 2006 Mar 15;571(Pt 3):605-18.
hippocampal neurons	5 μM	48 h	induced epileptiform activity in the majority of neurons (80%), which lasted more than 48 h after washing off CTZ	J Physiol. 2006 Mar 15;571(Pt 3):605-18.
rat hippocampal neurons	100 μM		Cyclothiazide significantly potentiated the AMPA-induced increase in intracellular free calcium ion concentration ([Ca2+]i), showing pronounced cell-to-cell variation.	Br J Pharmacol. 1998 Apr;123(7):1294-303.

Precautionary Statements-General
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P401
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Disposal
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CAS No.: 2259-96-3

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CAS No.: 2259-96-3

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Product Details of Cyclothiazide

Safety of Cyclothiazide

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed