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Chemical Structure| 296771-07-8 Chemical Structure| 296771-07-8

Structure of dCeMM2
CAS No.: 296771-07-8

Chemical Structure| 296771-07-8

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dCeMM2 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL5B ligase complex.

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Product Details of dCeMM2

CAS No. :296771-07-8
Formula : C16H11ClN6OS
M.W : 370.82
SMILES Code : O=C(CSC1=NC(NC2=CC=CC=C32)=C3N=N1)NC4=NC=C(C=C4)Cl
MDL No. :MFCD00824427
InChI Key :VFWVTIHYVUKNGR-UHFFFAOYSA-N
Pubchem ID :5286209

Safety of dCeMM2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of dCeMM2

Hedgehog

Isoform Comparison

Biological Activity

Description
dCeMM2 acts as a glue degrader, inducing ubiquitination and degradation of cyclin K by facilitating an interaction between CDK12-cyclin K and a CRL4B ligase complex[1].

Protocol

Bio Calculators
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2.70mL

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0.27mL

13.48mL

2.70mL

1.35mL

26.97mL

5.39mL

2.70mL

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