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Chemical Structure| 5928-25-6 Chemical Structure| 5928-25-6

Structure of Decursin
CAS No.: 5928-25-6

Chemical Structure| 5928-25-6

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Decursin ((+)-Decursin) is an effective anticancer agent and a cytotoxic and potent activator of protein kinase C (PKC). Decursin induces apoptosis and cell cycle arrest in the G1 phase. Decursin reduces the expression of CDK2, CDK4, CDK6, and cyclin D1 proteins at 48 hours. Decursin inhibits cell proliferation and migration and exhibits antitumor, anti-inflammatory, and analgesic activities.

Synonyms: (+)-Decursin

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Product Details of Decursin

CAS No. :5928-25-6
Formula : C19H20O5
M.W : 328.36
SMILES Code : CC(C)=CC(O[C@@H]1C(C)(C)OC2=C(C=C(C=CC(O3)=O)C3=C2)C1)=O
Synonyms :
(+)-Decursin
MDL No. :MFCD00272154

Safety of Decursin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Decursin

epigenetics
RTK
GPCR

Isoform Comparison

Biological Activity

Description
Decursin, identified as (+)-Decursin, serves as a potent anti-tumor agent with additional cytotoxic properties and the ability to activate protein kinase C significantly. It triggers apoptosis and causes cell cycle arrest in the G1 phase while reducing the expression of CDK2, CDK4, CDK6, and cyclin D1 proteins over 48 hours. Beyond its anti-tumor capacity, Decursin also displays anti-inflammatory and analgesic effects, inhibiting cell proliferation and migration[1].[2].[3].[4].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.45mL

6.09mL

3.05mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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