Home Cart Sign in  
Chemical Structure| 113411-17-9 Chemical Structure| 113411-17-9

Structure of DIF-3
CAS No.: 113411-17-9

Chemical Structure| 113411-17-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

DIF-3 promotes the degradation of GSK-3β, resulting in decreased expression levels of cyclin D1 and c-Myc, thereby inhibiting the activity of Wnt/β-catenin signaling pathway-related proteins. In the human cervical cancer cell line HeLa, DIF-3 exhibits potent anti-proliferative effects by inducing cyclin D1 degradation and inhibiting its mRNA expression.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of DIF-3

CAS No. :113411-17-9
Formula : C13H17ClO4
M.W : 272.72
SMILES Code : CCCCCC(C1=C(O)C=C(OC)C(Cl)=C1O)=O
MDL No. :MFCD05865230

Safety of DIF-3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of DIF-3

PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Description
DIF-3 reduces the expression levels of cyclin D1 and c-Myc by promoting their degradation via the activation of GSK-3β. It inhibits proteins related to the Wnt/β-catenin signaling pathway in DLD-1 cells and exerts a potent antiproliferative effect on the human cervical cancer cell line HeLa, inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.67mL

0.73mL

0.37mL

18.33mL

3.67mL

1.83mL

36.67mL

7.33mL

3.67mL

References

 

Historical Records

Categories