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Chemical Structure| 1809784-29-9 Chemical Structure| 1809784-29-9

Structure of DTP3
CAS No.: 1809784-29-9

Chemical Structure| 1809784-29-9

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DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of DTP3

CAS No. :1809784-29-9
Formula : C26H35N7O5
M.W : 525.60
SMILES Code : O=C(N[C@H](CC1=CC=CC=C1)C(N)=O)[C@H](NC([C@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)CCCNC(N)=N
English Name :(R)-2-((R)-2-Acetamido-3-(4-hydroxyphenyl)propanamido)-N-((R)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide
MDL No. :MFCD28348368
InChI Key :AOUZPXZGMZUQQS-YPAWHYETSA-N
Pubchem ID :86295191

Safety of DTP3

Related Pathways of DTP3

epigenetics
DNA
RTK
MAPK
JAK-STAT
pyroptosis
TLR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HepG2 cells up to 100 μM To evaluate the non-specific cytotoxic potential of DTP3, results showed DTP3 induced no change in any cytotoxicity parameters Toxicol Rep. 2019 Apr 19;6:369-379

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mouse Multiple myeloma xenograft model Intravenous bolus injection 10 mg/kg Once every day, once every other day, or once every 3 days for 14 days To evaluate the therapeutic efficacy of DTP3, results showed DTP3 significantly reduced tumor volume and nearly eliminated CD138+ cells Toxicol Rep. 2019 Apr 19;6:369-379
Nude mice PDX models Intraperitoneal injection 30 mg/kg Once daily for 15 days Combination of DTP3 with ZY0511 significantly inhibited HCC cell proliferation and tumor growth, with TGI increased to 66.12% MedComm (2020). 2023 May 24;4(3):e269

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.51mL

1.90mL

0.95mL

19.03mL

3.81mL

1.90mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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