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Chemical Structure| 131179-95-8 Chemical Structure| 131179-95-8

Structure of Efaproxiral
CAS No.: 131179-95-8

Chemical Structure| 131179-95-8

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Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

Synonyms: RSR13

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Efaproxiral

CAS No. :131179-95-8
Formula : C20H23NO4
M.W : 341.40
SMILES Code : CC1=CC(NC(=O)CC2=CC=C(OC(C)(C)C(O)=O)C=C2)=CC(C)=C1
Synonyms :
RSR13
English Name :2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid
MDL No. :MFCD00899086
InChI Key :BNFRJXLZYUTIII-UHFFFAOYSA-N
Pubchem ID :122335

Safety of Efaproxiral

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
INS-1 832/13 β-cells 1–100 nM 5 minutes To evaluate the effect of compounds on insulin secretion. Results showed that tazarotenic acid, efaproxiral, and bezafibrate significantly increased insulin secretion at nanomolar concentrations, with EC50 values of 5.73 nM, 14.2 nM, and 13.5 nM, respectively. J Enzyme Inhib Med Chem. 2021 Dec;36(1):377-383.

Protocol

Bio Calculators
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1 mM

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10 mM

2.93mL

0.59mL

0.29mL

14.65mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL

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