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Chemical Structure| 131179-95-8 Chemical Structure| 131179-95-8

Structure of Efaproxiral
CAS No.: 131179-95-8

Chemical Structure| 131179-95-8

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Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

Synonyms: RSR13

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Product Details of Efaproxiral

CAS No. :131179-95-8
Formula : C20H23NO4
M.W : 341.40
SMILES Code : CC1=CC(NC(=O)CC2=CC=C(OC(C)(C)C(O)=O)C=C2)=CC(C)=C1
Synonyms :
RSR13
MDL No. :MFCD00899086
InChI Key :BNFRJXLZYUTIII-UHFFFAOYSA-N
Pubchem ID :122335

Safety of Efaproxiral

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
INS-1 832/13 β-cells 1–100 nM 5 minutes To evaluate the effect of compounds on insulin secretion. Results showed that tazarotenic acid, efaproxiral, and bezafibrate significantly increased insulin secretion at nanomolar concentrations, with EC50 values of 5.73 nM, 14.2 nM, and 13.5 nM, respectively. PMC8759729

Protocol

Bio Calculators
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2.93mL

0.59mL

0.29mL

14.65mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL

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