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Chemical Structure| 2369751-30-2 Chemical Structure| 2369751-30-2

Structure of G150
CAS No.: 2369751-30-2

Chemical Structure| 2369751-30-2

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G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor for repression of dsDNA-triggered interferon expression, with an IC50 of 10.2 nM[1].

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Product Details of G150

CAS No. :2369751-30-2
Formula : C18H16Cl2N4O2
M.W : 391.25
SMILES Code : OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=CC=C(N)N=C4)=O
MDL No. :MFCD32067964

Safety of G150

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
G150 is a highly specific inhibitor of human cyclic GMP-AMP synthase (h-cGAS), with an IC50 of 10.2 nM. It suppresses interferon expression triggered by double-stranded DNA (dsDNA) and can be utilized in inflammatory research[1].

In Vitro:

Cell Line
Concentration Treated Time Description References
AB8/13 podocytes 10 µM 2 h To evaluate the effect of the cGAS inhibitor G150 on APOL1 expression. Results showed that G150 pretreatment did not significantly inhibit APOL1 protein expression induced by roxadustat or hypoxic conditions. PMC10970439

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.78mL

2.56mL

1.28mL

25.56mL

5.11mL

2.56mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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