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P03950-Human ANG-3d structure.jpg P03950-Human ANG-3d structure.jpg

Human ANG+SDS-PAGE.jpg Human ANG+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human ANG is a human recombinant angiogenin expressed in E. coli as an untagged protein. Belonging to the pancreatic ribonuclease family, it is predominantly expressed in the liver and functions as a tRNA-specific ribonuclease that inhibits protein synthesis by hydrolyzing tRNA. It potently stimulates angiogenesis, binds to actin on endothelial cell surfaces, and is internalized and transported to the nucleus. Its angiogenic activity is regulated by RNH1 and it is also associated with susceptibility to amyotrophic lateral sclerosis.

Synonyms: Recombinant Human ANG; Angiogenin; Ribonuclease 5

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human ANG

M.W : 14.27 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human ANG; Angiogenin; Ribonuclease 5
English Name :Recombinant Human ANG

Safety of Human ANG

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Biological Activity

Description
Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin is associated with susceptibility to amyotrophic lateral sclerosis, which is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord.
 

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