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P15514-Human AREG-3d structure.jpg P15514-Human AREG-3d structure.jpg

Human AREG+SDS-PAGE.jpg Human AREG+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human AREG is a human-derived protein expressed in E. coli as an untagged form. This single-pass transmembrane protein consists of 252 amino acids and belongs to the amphiregulin family, featuring one epidermal growth factor (EGF)-like domain. It is widely expressed in tissues such as ovary, placenta, lung, kidney, stomach, colon, and breast. Related to EGF and transforming growth factor alpha (TGF-α), it promotes normal epithelial cell proliferation by binding to EGF/TGF-α receptors and inhibits the growth of certain invasive cancer cell lines. It may also play a protective role in bleomycin-induced pneumonitis.

Synonyms: Recombinant Human AREG; Amphiregulin; AR

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human AREG

M.W : 11.4 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human AREG; Amphiregulin; AR
English Name :Recombinant Human AREG

Safety of Human AREG

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Description
Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy.
 

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