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P29965-Human CD40L-3d structure.jpg P29965-Human CD40L-3d structure.jpg

Human CD40L+BLI.jpg Human CD40L+BLI.jpg Measured by BLI, Human CD40 binds to Human CD40L with a Kd of 2.43 nM.

Measured by BLI, Human CD40 binds to Human CD40L with a Kd of 2.43 nM.

Human CD40L+ELISA.jpg Human CD40L+ELISA.jpg Measured by ELISA, Human CD40 binds to Human CD40L with an ED50 of 1-10 ng/ml.

Measured by ELISA, Human CD40 binds to Human CD40L with an ED50 of 1-10 ng/ml.

Human CD40L+SDS-PAGE.jpg Human CD40L+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human CD40L is a tag-free human recombinant protein expressed in E. coli. As a member of the TNF superfamily, it functions as the CD40 ligand and exists in both membrane-bound and soluble trimeric forms, both biologically active. It stimulates B cell proliferation and immunoglobulin secretion, induces monocytes to produce cytokines and exhibit tumoricidal activity, and synergistically promotes activated T cell proliferation accompanied by the production of IFN-γ, TNF-α, and IL-2.

Synonyms: Recombinant Human CD40L; CD40 Ligand; CD40-L

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human CD40L

M.W : 16.2 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human CD40L; CD40 Ligand; CD40-L
English Name :Recombinant Human CD40L

Safety of Human CD40L

Isoform Comparison

Biological Activity

Description
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
 

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