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O15263-Human DEFB4A-3d structure.jpg O15263-Human DEFB4A-3d structure.jpg

Human DEFB4A+SDS-PAGE.jpg Human DEFB4A+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human DEFB4A is a human beta-defensin 4A recombinant protein expressed in E. coli without any tags. Belonging to the beta-defensin family, this protein exhibits broad-spectrum antimicrobial activity and plays roles in inflammation and innate immune responses. It is predominantly highly expressed in the skin and tonsils, with additional distribution in respiratory, reproductive, and immune-related tissues. The mature peptide consists of 45 amino acids and shares 38% and 33% sequence similarity with its mouse and rat orthologs, respectively. It mediates innate epithelial defense functions.

Synonyms: Recombinant Human DEFB4A; Beta-Defensin 4A; Beta-Defensin 2

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human DEFB4A

M.W : 4.33 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human DEFB4A; Beta-Defensin 4A; Beta-Defensin 2
English Name :Recombinant Human DEFB4A

Safety of Human DEFB4A

Isoform Comparison

Biological Activity

Description
β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.
 

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