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P02794-Human FTH-3d structure.jpg P02794-Human FTH-3d structure.jpg

Human FTH+SDS-PAGE.jpg Human FTH+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human FTH is the human ferritin heavy chain 1 (FTH1) protein, expressed in E. coli and presented in a tag-free form. This intracellular iron storage protein possesses ferroxidase activity, playing a critical role in maintaining systemic iron homeostasis by oxidizing ferrous iron to ferric iron and storing it as non-toxic ferrihydrite. It forms a 24-subunit complex composed of both light and heavy chain subunits, participating in cellular iron delivery and iron uptake in developing kidney capsule cells. Variations in subunit composition may influence iron absorption and release in different tissues. Deficiency of FTH1 may contribute to neurodegenerative diseases.

Synonyms: Recombinant Human FTH; Ferritin heavy chain; FTH1

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human FTH

M.W : 21.2 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human FTH; Ferritin heavy chain; FTH1
English Name :Recombinant Human FTH

Safety of Human FTH

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Biological Activity

Description
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. Deficiency of ferritin proteins may cause several neurodegenerative diseases. Almost all living organisms can produce this protein, including algae, bacteria, higher plants, and animals.
 

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