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Q9GZX6-Human IL-22-3d structure.jpg Q9GZX6-Human IL-22-3d structure.jpg

Human IL-22+SDS-PAGE.jpg Human IL-22+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human IL-22 is a human-derived protein expressed in human cells and is an untagged protein. As a member of the IL-10 family, it is produced by activated dendritic cells and T cells, mediates inflammatory responses, and exerts its function by binding to the IL-22R1 and IL-10R2 receptor complex. It plays a role in modulating innate immunity, protecting epithelial cells, and its activity is regulated by IL-22BP.

Synonyms: Recombinant Human IL-22; Interleukin-22; IL-22

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human IL-22

M.W : 17.9 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human IL-22; Interleukin-22; IL-22
English Name :Recombinant Human IL-22

Safety of Human IL-22

Isoform Comparison

Biological Activity

Description
Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
 

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