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P15018-Human LIF-3d structure.jpg P15018-Human LIF-3d structure.jpg

Human LIF+Cell Based Assay.jpg Human LIF+Cell Based Assay.jpg Induces proliferation in TF-1 cells. ED50: 25-150 pg/ml (QC verified).

Induces proliferation in TF-1 cells. ED50: 25-150 pg/ml (QC verified).

Human LIF+SDS-PAGE.jpg Human LIF+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human LIF is a human-derived protein expressed in E. coli without any tags. This protein, also known as leukemia inhibitory factor (LIF), supports the long-term maintenance of embryonic stem cells and inhibits their spontaneous differentiation. It also exhibits multiple biological activities, including promoting cholinergic neuron differentiation and regulating stem cell pluripotency. The mature LIF proteins from human and mouse sources share 78% amino acid sequence homology, and human LIF demonstrates comparable bioactivity on both human and mouse cells.

Synonyms: Recombinant Human LIF; Leukemia Inhibitory Factor; LIF

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human LIF

M.W : 19.7 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human LIF; Leukemia Inhibitory Factor; LIF
English Name :Recombinant Human LIF

Safety of Human LIF

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Biological Activity

Description
Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid level. Human LIF is equally active on human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells than human LIF.
 

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