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Q13253-Human Noggin-3d structure.jpg Q13253-Human Noggin-3d structure.jpg

Human Noggin+Cell Based Assay.jpg Human Noggin+Cell Based Assay.jpg In the presence of BMP-4, inhibits alkaline phosphatase production in ATDC5 cells. ED50: 10-100 ng/mL (QC verified).

In the presence of BMP-4, inhibits alkaline phosphatase production in ATDC5 cells. ED50: 10-100 ng/mL (QC verified).

Human Noggin+SDS-PAGE.jpg Human Noggin+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human Noggin is a human-derived, untagged protein expressed in human cells. As an antagonist of bone morphogenetic proteins (BMPs), it is a secreted homodimeric glycoprotein. The mature form contains an N-terminal acidic region, a central basic heparin-binding domain, and a C-terminal cysteine knot structure. It shares high homology with Noggin proteins from various vertebrates, can bind heparin-associated proteoglycans, and functions by blocking BMP binding to their receptors. This protein is involved in stem cell culture and neural development regulation.

Synonyms: Recombinant Human Noggin; Noggin; NOG

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human Noggin

M.W : 23 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human Noggin; Noggin; NOG
English Name :Recombinant Human Noggin

Safety of Human Noggin

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Description
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mature Human Noggin contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine-knot structure. Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat bovine, equine and chicken Noggin, respectively. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons.
 

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