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P50591-Human TRAIL-3d structure.jpg P50591-Human TRAIL-3d structure.jpg

Human TRAIL+Cell Based Assay.jpg Human TRAIL+Cell Based Assay.jpg Induces cytotoxicity in L-929 cells with actinomycin D. ED50: 1-10 ng/ml.

Induces cytotoxicity in L-929 cells with actinomycin D. ED50: 1-10 ng/ml.

Human TRAIL+SDS-PAGE.jpg Human TRAIL+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Human TRAIL is a human-derived protein expressed in E. coli as an untagged form. This protein corresponds to human TNFSF10, a type II transmembrane protein featuring a TNF homology domain in its extracellular C-terminal region. It can interact with multiple receptors, including DR4 and DR5, which possess intrinsic death domains essential for apoptosis activation. TRAIL holds therapeutic potential for cancer treatment, exhibiting cytotoxicity and inducing apoptosis in most malignant cells while sparing normal cells.

Synonyms: Recombinant Human TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Human TRAIL

M.W : 19.5 KDa
SMILES Code : NONE
Synonyms :
Recombinant Human TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand
English Name :Recombinant Human TRAIL

Safety of Human TRAIL

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Description
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
 

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