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CAS No. :	881970-80-5
Formula :	C₂₁H₁₃FN₂O₂S
M.W :	376.40
SMILES Code :	O=C1C(C2=CN3C(SC(CC4=CC=C(F)C=C4)=C3)=N2)=CC5=C(O1)C=CC=C5

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

MeT-5A	7.5, 15, 50 µM	72 hours	To evaluate the effect of iMDK on the proliferation of MeT-5A cells, results showed significant inhibition of cell proliferation at the highest dose (50 µM).	Cancer Gene Ther. 2024 Nov;31(11):1708-1720
MSTO-211H	7.5, 15, 50 µM	72 hours	To evaluate the effect of iMDK on the proliferation of MSTO-211H cells, results showed significant inhibition of cell proliferation at the highest dose (50 µM).	Cancer Gene Ther. 2024 Nov;31(11):1708-1720
colon cancer cell line HCT116	100nM	48 hours	Inhibited MDK expression, reversed IFN-γ-activated EMT and tumor metastasis	Front Oncol. 2022 Jun 7;12:885656
breast cancer cell line BT549	100nM	48 hours	Inhibited MDK expression, reversed IFN-γ-activated EMT and tumor metastasis	Front Oncol. 2022 Jun 7;12:885656
cervical carcinoma cell line CaSki	100nM	48 hours	Inhibited MDK expression, reversed IFN-γ-activated EMT and tumor metastasis	Front Oncol. 2022 Jun 7;12:885656
lung cancer cell line A549	100nM	48 hours	Inhibited MDK expression, reversed IFN-γ-activated EMT and tumor metastasis	Front Oncol. 2022 Jun 7;12:885656
kidney cancer cell line Caki-1	100nM	48 hours	Inhibited MDK expression, reversed IFN-γ-activated EMT and tumor metastasis	Front Oncol. 2022 Jun 7;12:885656
HUVEC cells	10 μM	5 hours	To evaluate the effect of iMDK on HUVEC tube formation, results showed that iMDK combined with PD0325901 significantly inhibited tube formation	Exp Cell Res. 2015 Jul 15;335(2):197-206
A549 cells	0.25 μM	72 hours	To evaluate the inhibitory effect of iMDK on A549 cell proliferation, results showed that iMDK alone did not inhibit cell proliferation, but significantly inhibited cell proliferation when combined with PD0325901	Exp Cell Res. 2015 Jul 15;335(2):197-206
H520 cells	0.125 μM	72 hours	To evaluate the inhibitory effect of iMDK on H520 cell proliferation, results showed that iMDK significantly inhibited cell proliferation	Exp Cell Res. 2015 Jul 15;335(2):197-206
H2009 cells	1 μM	24 hours	To evaluate the effect of iMDK on H2009 cell colony formation, results showed that iMDK significantly reduced colony formation	Exp Cell Res. 2015 Jul 15;335(2):197-206
H441 cells	2.5 μM	72 hours	To evaluate the inhibitory effect of iMDK on H441 cell proliferation, results showed that iMDK significantly inhibited cell proliferation	Exp Cell Res. 2015 Jul 15;335(2):197-206
SKOV3 human ovarian cancer cell line	100 nM		To assess the effect of iMDK on IFN-γ-induced EMT and metastasis, found that iMDK significantly suppressed IFN-γ-driven EMT and metastasis	Biomedicines. 2022 Dec 21;11(1):8
SKOV3 human ovarian cancer cell line	6.6 nM	48 hours	To assess the effect of iMDK on IFN-γ-induced anti-proliferation, found that iMDK significantly enhanced the anti-tumor activity of IFN-γ	Biomedicines. 2022 Dec 21;11(1):8
NHLF normal human lung fibroblast cells	5-500 nM	48 hours	iMDK had no significant effect on NHLF cells	PLoS One. 2013 Aug 16;8(8):e71093
A549 lung adenocarcinoma cells	5-500 nM	48 hours	iMDK had no significant effect on A549 cells	PLoS One. 2013 Aug 16;8(8):e71093
H520 human lung squamous cell carcinoma cells	5-500 nM	48 hours	iMDK inhibited H520 cell growth	PLoS One. 2013 Aug 16;8(8):e71093
H441 lung adenocarcinoma cells	5-500 nM	48 hours	iMDK inhibited H441 cell growth by suppressing the PI3K pathway and inducing apoptosis	PLoS One. 2013 Aug 16;8(8):e71093
Caco-2 cells	25 nM	72 hours	To investigate the effect of iMDK on the permeability of tight junctions in MPA-treated Caco-2 cell monolayers. Results showed that iMDK significantly inhibited MPA-induced compromised TJ integrity.	Front Physiol. 2017 Jun 26;8:438
neural progenitors (NP)	0.5 μM	5 days	Evaluate the effect of idebenone on NP cell viability, showing no significant change at 0.5 μM concentration.	Biogerontology. 2017 Aug;18(4):665-677
early neural progenitors (eNP)	0.5 μM	5 days	Evaluate the effect of idebenone on eNP cell viability, showing a significant increase to 138.19% at 0.5 μM concentration.	Biogerontology. 2017 Aug;18(4):665-677
neural stem cells (NSC)	0.5 μM	5 days	Evaluate the effect of idebenone on NSC cell viability, showing a significant increase to 130% at 0.5 μM concentration.	Biogerontology. 2017 Aug;18(4):665-677

Nude mice	Xenograft model	Intraperitoneal injection	9 mg/kg	Once every two days	IMDK significantly reduced tumor volume and weight and decreased lung metastasis rates	Cancers (Basel). 2020 Aug 24;12(9):2402
BALB/c nude mice	H441 cell xenograft model	IMDK: intraperitoneal injection, PD0325901: oral administration	iMDK: 9 mg/kg, PD0325901: 5 mg/kg	IMDK: once daily, PD0325901: five times per week, for 11 days	To evaluate the inhibitory effect of iMDK combined with PD0325901 on H441 cell xenograft tumor growth, results showed that the combination therapy significantly inhibited tumor growth and tumor-associated angiogenesis	Exp Cell Res. 2015 Jul 15;335(2):197-206
BALB/c nude mice	H441 lung adenocarcinoma xenograft model	Intraperitoneal injection	9 mg/kg	3 or 5 times per week for 10 days	IMDK significantly inhibited tumor growth by suppressing the PI3K pathway and inducing apoptosis	PLoS One. 2013 Aug 16;8(8):e71093

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CAS No.: 881970-80-5

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CAS No.: 881970-80-5

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed