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Chemical Structure| 1854943-32-0 Chemical Structure| 1854943-32-0

Structure of Iruplinalkib
CAS No.: 1854943-32-0

Chemical Structure| 1854943-32-0

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Iruplinalkib (WX-0593) is an orally effective ALK and ROS1 tyrosine kinase inhibitor with selectivity and has shown good safety and antitumor activity in advanced NSCLC with ALK or ROS1 rearrangements.

Synonyms: WX-0593

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Product Details of Iruplinalkib

CAS No. :1854943-32-0
Formula : C29H38ClN6O2P
M.W : 569.08
SMILES Code : CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC5(CCN(C)CC5)CC4)C=C3OC)=NC=C2Cl)=O
Synonyms :
WX-0593
MDL No. :MFCD34789645

Safety of Iruplinalkib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Iruplinalkib

RTK

Isoform Comparison

Biological Activity

Description
Iruplinalkib (WX-0593) is a potent, selective, and orally bioavailable inhibitor of ALK and ROS1 tyrosine kinases, displaying favorable safety and promising antitumor efficacy in advanced NSCLC with ALK or ROS1 rearrangements[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05991895 Non-small Cell Lung Cancer (NS... More >>CLC) Less << RECRUITING 2025-07-26 Shandong Cancer Hospital and I... More >>nstitute, Jinan, Shandong, China Less <<
NCT05801107 Non-small Cell Lung Cancer PHASE2 ACTIVE_NOT_RECRUITING 2023-12-15 Shanghai Jiao Tong University ... More >>Chest Hospital, Shanghai, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.57mL

3.51mL

1.76mL

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