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Chemical Structure| 1462267-08-8 Chemical Structure| 1462267-08-8

Structure of ML266
CAS No.: 1462267-08-8

Chemical Structure| 1462267-08-8

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ML266 is a glucocerebrosidase activator and a non-inhibitory chaperone of glucocerebrosidase.

4.5 *For Research Use Only !

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Product Details of ML266

CAS No. :1462267-08-8
Formula : C24H22BrN3O4
M.W : 496.35
SMILES Code : O=C(NCC(N(C)C1=CC=CC=C1)=O)C2=CC=CC=C2OCC(NC3=CC=C(Br)C=C3)=O
MDL No. :MFCD29477343

Safety of ML266

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
ML266 acts as a chaperone for glucocerebrosidase (GCase) with an IC50 of 2.5 µM. It binds to GCase, facilitating the transport of the mutant protein to the lysosome and restoring GCase activity. ML266 does not inhibit the enzymatic function of GCase. This makes ML266 a candidate for research into Gaucher disease[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.07mL

2.01mL

1.01mL

20.15mL

4.03mL

2.01mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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