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P10148-Mouse CCL2-3d structure.jpg P10148-Mouse CCL2-3d structure.jpg

Mouse CCL2+SDS-PAGE.jpg Mouse CCL2+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Mouse CCL2 is a mouse-derived recombinant protein expressed in E. coli and is an untagged protein. This protein, also known as C-C motif chemokine ligand 2, belongs to the C-C or β-chemokine family and shares certain amino acid sequence homology with CCL2 from various species. It is primarily produced by fibroblasts and other cell types, exhibits chemotactic activity, and can induce the release of enzymes, cytokines, and histamine. It promotes Th2 polarization and is involved in pathological processes such as atherosclerosis.

Synonyms: Recombinant Mouse CCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse CCL2

M.W : 8.5 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse CCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1
English Name :Recombinant Mouse CCL2

Safety of Mouse CCL2

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Biological Activity

Description
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.
 

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