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P15655-Mouse FGFb-3d structure.jpg P15655-Mouse FGFb-3d structure.jpg

Mouse FGFb+Cell Based Assay.jpg Mouse FGFb+Cell Based Assay.jpg Induces proliferation in BALB/c 3T3 cells. ED50: 0.3-1.8 ng/ml (QC verified).

Induces proliferation in BALB/c 3T3 cells. ED50: 0.3-1.8 ng/ml (QC verified).

Mouse FGFb+SDS-PAGE.jpg Mouse FGFb+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Mouse EGF (C-6His) is a mouse-derived recombinant protein, expressed in Escherichia coli with a C-terminal 6×His tag. It is a low-molecular-weight polypeptide belonging to the Epidermal Growth Factor family, and has been reported in developmental biology studies to possess biological activities that promote cell proliferation, differentiation and survival. First isolated from the mouse submandibular gland, it is also present in multiple human tissues and can be used in studies on the molecular mechanisms underlying mucosal cell protection and repair.

Synonyms: Recombinant Mouse FGFb; Fibroblast Growth Factor 2; FGF-2

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse FGFb

M.W : 17.15 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse FGFb; Fibroblast Growth Factor 2; FGF-2
English Name :Recombinant Mouse FGFb

Safety of Mouse FGFb

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Biological Activity

Description
FGF basic (Basic Fibroblast Growth Factor) is one of 22 mitogenic proteins in the FGF family, with 35%-60% amino acid sequence identity among family members; unlike other FGFs, acidic and basic FGF lack signal peptides and are secreted via an alternative pathway. The 17 kDa mouse FGF basic sequence shares 98% amino acid identity with that of rat, and 95% identity with human, bovine, and sheep FGF basic. At the molecular mechanism level, the binding of FGF to heparin or cell surface heparan sulfate proteoglycans (HSPG) is essential for the binding, dimerization, and activation of tyrosine kinase FGF receptors, and FGF basic also exhibits low-affinity binding to other proteins, polysaccharides, and lipids. Its expression is nearly ubiquitous in tissues, but disruption of the mouse FGF basic gene results in a relatively mild phenotype, suggesting functional compensation by other FGF family members. In the fields of developmental biology, neurobiology, and vascular biology research, FGF basic is involved in regulating the molecular mechanisms related to angiogenesis, embryonic development and differentiation, and neuronal function; transgenic overexpression of FGF basic leads to excessive proliferation and angiogenesis, which can serve as a model for studying abnormalities of related molecular pathways.
 

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