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Mouse IL-12+SDS-PAGE.jpg Mouse IL-12+SDS-PAGE.jpg Greater than 90% as determined by reducing SDS-PAGE.

Greater than 90% as determined by reducing SDS-PAGE.

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Recombinant Mouse IL-12 is a mouse-derived recombinant protein expressed in human cells without tags. It is a heterodimeric cytokine composed of two subunits, 40 kDa (p40) and 35 kDa (p35). The p40 and p35 subunits share 70% and 60% amino acid sequence homology with their human counterparts, respectively. This protein promotes the differentiation of both mouse and human T cells into Th1 cells, stimulates the production of IFN-γ and TNF-α, enhances the cytotoxic activity of NK cells and CD8+ T cells, and plays a critical role in immune regulation.

Synonyms: Recombinant Mouse IL-12; IL-12; Interleukin 12

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse IL-12

M.W : 35.8&21.7 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse IL-12; IL-12; Interleukin 12
English Name :Recombinant Mouse IL-12

Safety of Mouse IL-12

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Description
Mouse IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Human and mouse IL‑12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. While mouse IL‑12 is active on both human and mouse cells, human IL‑12 is not active on murine cells. It is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
 

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