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P10749-Mouse IL-1b-3d structure.jpg P10749-Mouse IL-1b-3d structure.jpg

Mouse IL-1b+SDS-PAGE.jpg Mouse IL-1b+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Mouse IL-1β is a mouse-derived recombinant interleukin-1 beta protein, expressed in E. coli and provided in an untagged form. This protein belongs to the IL-1 family, sharing structural similarity with IL-1α but encoded by a different gene, and can bind to the same cell surface receptors. The mature forms of mouse and human IL-1β share approximately 75% amino acid sequence homology, and human IL-1β exhibits activity on mouse cells. The active 17.5 kDa form is generated via proteolytic cleavage of the 31 kDa precursor protein and is involved in inflammatory responses, infection, and microbial endotoxin signaling.

Synonyms: Recombinant Mouse IL-1b; Interleukin-1 Beta; IL-1 Beta

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse IL-1beta

M.W : 17.4 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse IL-1b; Interleukin-1 Beta; IL-1 Beta
English Name :Recombinant Mouse IL-1beta

Safety of Mouse IL-1beta

Isoform Comparison

Biological Activity

Description
Interleukin-1 (IL-1) designates two proteins, IL-1α and IL-1β, which are the products of distinct genes, but recognize the same cell surface receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1β, designated interleukin 1β-converting enzyme (ICE), has been described. Mature human and mouse IL-1β share approximately 75% amino acid sequence identity and human IL-1β has been found to be active on murine cell lines.
 

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