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P07750-Mouse IL-4-3d structure.jpg P07750-Mouse IL-4-3d structure.jpg

Mouse IL-4+Cell Based Assay.jpg Mouse IL-4+Cell Based Assay.jpg Induces proliferation in NFS-60 cells. ED50: 182 pg/mL (Regularly tested).

Induces proliferation in NFS-60 cells. ED50: 182 pg/mL (Regularly tested).

Mouse IL-4+SDS-PAGE.jpg Mouse IL-4+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

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Recombinant Mouse IL-4 is a tag-free recombinant protein derived from mouse and expressed in E. coli. As a Th2 cytokine, it exhibits pleiotropic immunoregulatory functions, containing three intrachain disulfide bonds and forming a four-α-helix bundle structure. It exerts its biological effects through a dual-receptor complex. Primarily produced by Th2-type CD4+ T cells, it promotes B cell activation, induces class switching to IgG1 and IgE, drives Th2 cell differentiation, and activates eosinophils and other immune cells. This cytokine plays a pivotal role in the pathogenesis of allergic inflammation and asthma.

Synonyms: Recombinant Mouse IL-4; Interleukin-4; B-cell IgG differentiation factor

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse IL-4

M.W : 13.4 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse IL-4; Interleukin-4; B-cell IgG differentiation factor
English Name :Recombinant Mouse IL-4

Safety of Mouse IL-4

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Description
Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α­helix structure. IL­4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL­4 is primarily expressed by Th2­biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
 

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