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Q544U0-Mouse Leptin-3d structure.jpg Q544U0-Mouse Leptin-3d structure.jpg

Mouse Leptin+SDS-PAGE.jpg Mouse Leptin+SDS-PAGE.jpg Greater than 95% as determined by reducing SDS-PAGE.

Greater than 95% as determined by reducing SDS-PAGE.

Mouse Leptin+ELISA.jpg Mouse Leptin+ELISA.jpg Measured by ELISA, Mouse LEPR binds to Mouse Leptin with an ED50 of 1.16 ng/ml.

Measured by ELISA, Mouse LEPR binds to Mouse Leptin with an ED50 of 1.16 ng/ml.

Mouse Leptin+BLI.jpg Mouse Leptin+BLI.jpg Measured by BLI, Recombinant Mouse LEPR binds to Recombinant Mouse Leptin with a Kd of 0.196 nM.

Measured by BLI, Recombinant Mouse LEPR binds to Recombinant Mouse Leptin with a Kd of 0.196 nM.

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Recombinant Mouse Leptin is a tag-free protein derived from mouse and expressed in E. coli. Secreted by white adipocytes, it regulates food intake and energy homeostasis by acting through the hypothalamic OB-R signaling pathway. Animal studies demonstrate its effects on weight reduction and glucose regulation. Deficiency of leptin is associated with increased risks of obesity and diabetes, as well as reduced metabolic rate. The amino acid sequence of recombinant mouse leptin shares approximately 84% homology with human leptin.

Synonyms: Recombinant Mouse Leptin; Leptin; Obese Protein

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Mouse Leptin

M.W : 16.1 KDa
SMILES Code : NONE
Synonyms :
Recombinant Mouse Leptin; Leptin; Obese Protein
English Name :Recombinant Mouse Leptin

Safety of Mouse Leptin

Isoform Comparison

Biological Activity

Description
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
 

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